Description: Kernicterus by David W. McCandless Kernicterus (bilirubin encephalopathy) is a highly interesting example of metabolic encephalopathy. It fills all the characteristics of a metabolic encephalopathy in that it can develop rapidly, produces signature signs and symptoms, and is amenable to successful treatment. FORMAT Paperback LANGUAGE English CONDITION Brand New Publisher Description Kernicterus (bilirubin encephalopathy) is a highly interesting example of metabolic encephalopathy. It fills all the characteristics of a metabolic encephalopathy in that it can develop rapidly, produces signature signs and symptoms, and is amenable to successful treatment. In the absence of treatment kernicterus can produce devastating sequelae and death.The present volume will examine the biochemistry and physiology of bilirubin as well as its hepatic metabolism and renal excretion. Chapters will elaborate bodily disposition of bilirubin and its neuropathology. Both early treatments and current therapy will be discussed in detail. Phototherapy will be presented, and its efficacy and influence on incidence thoroughly examined. Back Cover Kernicterus is an excellent example of a metabolic encephalopathy. It clearly produces a biochemical lesion early when bilirubin first enters the brain. If initial staining can be minimized or reversed, permanent damage can be avoided. This takes strict attention to detail, and a keen ability for timely and accurate diagnosis. The potential for improvement/reversal argues strongly for increased awareness by all health care workers. Kernicterus will examine the history, biochemistry, physiology, neuropathology, etc., of bilirubin. New concepts of how bilirubin is toxic, and damages the acoustic system will be thoroughly examined. The promising new treatment possibility using gene therapy will be examined in detail. This therapy has been successfully used in the excellent animal model, the Gunn rat. Translation of these exciting results to newborn infants is well underway. About the Author: Dr. David W. McCandless is the John J. Sheinin Professor of Anatomy in the Department of Cell Biology and Anatomy at The Chicago Medical School, Rosalind Franklin University, North Chicago, IL, USA. He has over 35 years of laboratory research into basic mechanisms of various metabolic encephalopathies. He is the Founding Editor of the journal Metabolic Brain Disease (Springer), now in its 27th year. Dr. McCandless has been on the faculty or research staff at The University of Vermont College of Medicine, NIH-NINCDS, University of Texas Medical School at Houston, and The Chicago Medical School, and was a visiting professor at Washington University School of Medicine. Dr. McCandless has published in journals such as The J. Clinical Investigation, Nature, Proc. National Academy of Sciences, Amer. J. of Physiology, Brain Research, J. Neurochemistry, Teratology, Epilepsia, Stroke, and many others. Author Biography Dr. David W. McCandless is the John J. Sheinin Professor of Anatomy in the Department of Cell Biology and Anatomy at The Chicago Medical School, Rosalind Franklin University, North Chicago, IL, USA. He has over 35 years of laboratory research into basic mechanisms of various metabolic encephalopathies. He serves as Editor-in Chief of the journal Metabolic Brain Disease (Springer), now in its 26th year. Dr. McCandless has been on the faculty or research staff at The University of Vermont College of Medicine, NIH-NINCDS, University of Texas Medical School at Houston, and The Chicago Medical School, and was a visiting professor at Washington University School of Medicine.Dr. McCandless has published in journals such as The J. Clinical Investigation, Nature, Proc. National Academy of Sciences, Amer. J. of Physiology, Brain Research, J. Neurochemistry, Teratology, Epilepsia, Stroke, and many others Table of Contents Dedication page.- Preface.- Acknowledgement.- Key words.-Chapter 1 Prologue: Hyperbilirubinemia, kernicterus, and world health concerns.-Chapter 2 History of bilirubin.-Chapter 3 Biochemistry and physiology of bilirubin.- Chapter 4 Prematurity.- Chapter 5 Erythroblastosis fetalis.- Chapter 6 Gunn rats.- Chapter 7 Crigler-Najjar Syndrome.- Chapter 8 Neuropathology of kernicterus.- Chapter 9 Bilirubin and energy metabolism.- Chapter 10 Bilirubin and other biochemical changes.- Chapter 11 Jaundice and breast milk.- Chapter 12 Jaundice and malaria.- Chapter 13 Jaundice and congenital pyloric stenosis.- Chapter 14 Phototherapy for hyperbilirubinemia.- Chapter 15 Non phototherapy treatment.- Chapter 16 Hyperbilirubinemia revisited.- Chapter 17 Auditory brainstem response.- Chapter 18 Progressive familial intrahepatic cholestasis.- Chapter 19 Kernicterus in older children and adults.- Chapter 20 Cerebral palsy and counseling.- Chapter 21 Neurological sequelae from jaundice.- Chapter 22 Neurobehavioral teratology.- Chapter 23 Gene therapy for hyperbilirubinemia.- Chapter 24 Epilog: Kernicterus: comments and future directions.- Appendix.- References.- Index. Review From the reviews:"Hyperbilirubinemia and the prevention of development of neurological pathology and/ or death due to kernicterus in newborns is a significant concern for physicians and allied healthcare workers worldwide. … Kernicterus is a worthy addition to the clinical neuroscience literature as a treatise on a condition that preferentially attacks critical brain regions. … it should be read widely by clinicians and public health officers confronted by issues related to the early diagnosis, treatment and rehabilitation of individuals suffering from kernicterus." (Medical Science Books, May, 2011) Review Quote From the reviews:Hyperbilirubinemia and the prevention of development of neurological pathology and/ or death due to kernicterus in newborns is a significant concern for physicians and allied healthcare workers worldwide. … Kernicterus is a worthy addition to the clinical neuroscience literature as a treatise on a condition that preferentially attacks critical brain regions. … it should be read widely by clinicians and public health officers confronted by issues related to the early diagnosis, treatment and rehabilitation of individuals suffering from kernicterus. (Medical Science Books, May, 2011) Feature The book is designed to examine the biochemistry and physiology of bilirubinNew concepts relating to the way in which bilirubin is toxicThis volume with examine bilirubins formation, metabolism, transport and excretion in detail Details ISBN1617797014 Author David W. McCandless Publisher Humana Press Inc. Series Contemporary Clinical Neuroscience ISBN-10 1617797014 ISBN-13 9781617797019 Format Paperback Imprint Humana Press Inc. Place of Publication Totowa, NJ Country of Publication United States DEWEY 616.832 Birth 1941 Year 2014 Publication Date 2014-03-24 Short Title KERNICTERUS Language English Media Book Pages 286 Edition 2011th AU Release Date 2014-03-24 NZ Release Date 2014-03-24 US Release Date 2014-03-24 UK Release Date 2014-03-24 Edition Description 2011 ed. Alternative 9781441965547 Audience Professional & Vocational Illustrations XIV, 286 p. We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:96372641;
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ISBN-13: 9781617797019
Book Title: Kernicterus
Number of Pages: 286 Pages
Language: English
Publication Name: Kernicterus
Publisher: Humana Press Inc.
Publication Year: 2014
Subject: Medicine, Biology, Healthcare System
Item Height: 235 mm
Item Weight: 462 g
Type: Textbook
Author: David W. Mccandless
Item Width: 155 mm
Format: Paperback
